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ประสบความสาเร็จในการอ่านตามแบบฝึกหัดที่กาหนดอย่างดีมาก
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cleaving the polyubiquitin chain of substrates. Rpt1-6, an ATPase ring, is involved in substrate protein unfolding and translocation into the channel of the 20S. Rpn13 and Rpn10 (a lid subunit) serve as ubiquitin receptors. Rpn1 can bind into the ubiquitin shuttle receptors and cytoplasmic deubiquitinases. b A simplified product with the proteasome regulatory particle 11S, which happens to be also termed PA28. It is actually an activator with the proteasome. c Assembly product of mammalian proteasome.
ตัวอย่างบทสนทนาสอบถามและบอกเล่าถึงความรู้สึก
p62/SQSTM1-droplet serves to be a System for autophagosome formation สล็อตเว็บตรง and anti-oxidative tension reaction
A further challenge would be the degradation method. It's been documented that Pan-cathepsin inhibitors and bafilomycin A1 can cease the degradation of p62 [35]. We also needs to acquire UPS into account, Considering that the p62 protein degree increases on proteasome inhibition, as described earlier mentioned.
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ภาษากับของไทยและนาไปใช้อย่างมีเหตุผล
In combination with the failure of transportation of suitable ubiquitinated protein targets and so resultant positional isolation, abnormal p62 aggregates may functionally inactivate the regulators with the UPS, like the p97/VCP (64). In this method, the binding amongst the PB1 domain and UBA area of p62 plus the proteasome regulator is critically necessary.
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Additionally, the deficiency of proteasome parts raises the transcription and protein synthesis of p62